Development of Bioaffinity Chromatography for Uricase Purification
Salleh, Abu Bakar (1980) Development of Bioaffinity Chromatography for Uricase Purification. Pertanika, 3 (2). pp. 97-102.
The uricase inhibitors urate, xanthine, oxonate and cyanurate were tried as ligands, for preparing bioaffinity support for chromatographic separation of uricase. Only derivatised purines showed inhibitory properties, whereas derivatised s-triazines seemed to lose their absorptive capacity. Chromatographic separation on a bioaffinity support produced higher yield and better purification of Uricase than conventional chromatographic technique.
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