Bioactive constituents of melicope bonwickii and m. lunu-ankeda (rutaceae).
Mohd. Hashim , Najihah and Komala, Ismiarni and Rahmani, Mawardi and Ee, Gwendoline Cheng Lian and Mohd Ismail, Hazar and Sukari, Mohd Aspollah and Rahmat, Asmah (2005) Bioactive constituents of melicope bonwickii and m. lunu-ankeda (rutaceae). In: International Science Congress (ISC), 3-6 Aug 2005, Putra World Trade Center, Kuala Lumpur.
The used of natural products from plant source with therapeutic properties is ancient as human civilization. Currently about 25% of modern drugs prescribed worldwide come from plants and 121 such active compounds are being used. Of the 252 drugs considered as basic and essential by World Health Organization (WHO), 11% are exclusively of plants origin and a significant number are synthetic drugs obtained from natural precursors. Deatiled phytochemical study of Melicope bonwickii (F. Muell) T. Hartley revealed the presence of four furoquinoline alkaloids in which one is a rare new chlorine-containing compound, 7(2',-hydroxy-3'-chloroprenyloxy)-4-methoxyfuroquinoline, three known alkaloids 7-(2',3'-epoxyprenyloxy)-4-methoxyfuroquinoline, evellerine and kokusaginine together with a known dipeptide, aurantiamide acetate. From leaves of Melicope lunu-ankeda (Geartn) T. Hartley, two phenylpropanoid derivatives,p-)-geranylcoumaric acid and sesamin, a quinolone alkaloid and a flavanoid were isolated and identified. The ectracts and the isolated compounds were evaluated for their antioxidant, cytotoxity and antimicrobial activities. The new furoquinoline alkaloid and 7-(2',3'-epoxyprenyloxy)-4-methoxyfuroquinoline exhibited significant cytotoxic activity against cervical cancer (Hela) cell line with IC50 values were found to be 6.0 and 11.4 µg/ml, respectively.
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