Self built of laboratory scale supercritical anti solvent system

Chong, G. H. and R., Yunus and Choong, Thomas Shean Yaw and Abdullah, N. and Spotar, S. Y. (2010) Self built of laboratory scale supercritical anti solvent system. In: 9th Conference on Supercritical Fluids and Their Applications, 5-8 September 2010, Sorrento, Italy. (Unpublished)

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Abstract

Supercritical fluid (SCF) particles formation technique gained a significant attention mainly in the pharmaceutical, cosmetic and paints. However, the scarcity of information on the design and process for this type of laboratory scale equipment is a significant drawback to the technological progress. Therefore, the purpose of this study was to design and build a laboratory supercritical anti solvent (SAS) system for producing microparticles and microcapsules of acetaminophen. The operating conditions of the constructed system affected the yield. The optimum operating conditions were then determined as: 110 bars, 35° C, 35 mg/ml of polymer concentration and 1.75 ml/min of feed flow rate. The microparticles and microcapsules were characterized on its morphology (scanning electron microscopy), size distribution (particle size analyzer), thermal properties (thermo gravimetetric analyzer) and crystallographic (X-ray powder diffraction). The in vitro drug released of the microparticles and microcapsules were also investigated. The results revealed a more homogenous microparticle size distribution, a change in the crystalinity and maintained of drug thermal stability after the SAS process. Furthermore, the microcapsules prolong the drug released significantly in the in vitro study.

Item Type:Conference or Workshop Item (Paper)
Keyword:supercritical fluid; anti solvent; SAS; particle formation
Subject:Supercritical fluids
Subject:Solvents
Faculty or Institute:Faculty of Food Science and Technology
ID Code:18210
Deposited By: Samsida Samsudin
Deposited On:25 Nov 2011 03:41
Last Modified:16 Dec 2013 08:15

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