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Antioxidant and antiacetylcholinesterase activities of Pluchea indica less


Ab. Rahim, Noridayu and Hii, Yueh Feng and Abas, Faridah and Shaari, Khozirah and Lajis, Md Nordin (2010) Antioxidant and antiacetylcholinesterase activities of Pluchea indica less. In: 11th Eurasia Conference on Chemical Sciences, 6-10 Oct. 2010, Jordan. (pp. 1-17).

Abstract / Synopsis

This study was undertaken to evaluate the antioxidant and acetylcholinesterase inhibition properties of stems and leaf of hexane and methanolic extracts of Pluchea indica. Methanolic extract of leaves showed the highest antioxidant activity (IC50= 24.45 ± 0.34 μg/ml) and total phenolic contents (573.52 ± 6.2 mg GAE/100g crude extract), in DPPH radical scavenging and Folin-Ciocalteu assays respectively, however, it failed to inhibit acetylcholinesterase in TLC bioautographic detection. The rest of plant extracts, included methanolic extract of stems, hexane extract of both leaves and stems, were detected to have acetylcholinesterase inhibitory properties. Hexane extract of both leaves and stems exhibited lower or negligible level of antioxidant activity and phenolic contents. Overall, the best result was obtained with methanolic extract of stems, which exhibited moderate DPPH radical scavenging ability (IC50= 83.74 ± 0.89 μg/ml) together with antiacetylcholinesterase properties.

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Additional Metadata

Item Type: Conference or Workshop Item (Paper)
Subject: Soils - Phenolic acid content
Subject: Acetylcholinesterase
Divisions: Faculty of Food Science and Technology
Keywords: Total phenolic content; DPPH, acetylcholinesterase; Pluchea indica
Depositing User: Erni Suraya Abdul Aziz
Date Deposited: 16 Jun 2011 17:28
Last Modified: 18 Sep 2015 10:30
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