Antioxidant and antiacetylcholinesterase activities of Pluchea indica less
Ab. Rahim, Noridayu and Hii, Yueh Feng and Abas, Faridah and Shaari, Khozirah and Lajis, Md Nordin (2010) Antioxidant and antiacetylcholinesterase activities of Pluchea indica less. In: 11th Eurasia Conference on Chemical Sciences, 6-10 Oct. 2010, Jordan. pp. 1-17.
This study was undertaken to evaluate the antioxidant and acetylcholinesterase inhibition properties of stems and leaf of hexane and methanolic extracts of Pluchea indica. Methanolic extract of leaves showed the highest antioxidant activity (IC50= 24.45 ± 0.34 μg/ml) and total phenolic contents (573.52 ± 6.2 mg GAE/100g crude extract), in DPPH radical scavenging and Folin-Ciocalteu assays respectively, however, it failed to inhibit acetylcholinesterase in TLC bioautographic detection. The rest of plant extracts, included methanolic extract of stems, hexane extract of both leaves and stems, were detected to have acetylcholinesterase inhibitory properties. Hexane extract of both leaves and stems exhibited lower or negligible level of antioxidant activity and phenolic contents. Overall, the best result was obtained with methanolic extract of stems, which exhibited moderate DPPH radical scavenging ability (IC50= 83.74 ± 0.89 μg/ml) together with antiacetylcholinesterase properties.
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