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Synthesis, characterization and bioactivity of mixed-ligandCu(II) complexes containing Schiff bases derived fromS-benzyldithiocarbazate and saccharinate ligand and the X-raycrystal structure of the copper-saccharinate complex containing S-benzyl-b-N-(Synthesis, characterization and bioactivity of mixed-ligandCu(II) complexes containing Schiff bases derived fromS-benzyldithiocarbazate and saccharinate ligand and the X-raycrystal structure of the copper-saccharinate complex containing S-benzyl-b-N-(acet).


Citation

Crouse, Karen Anne and Mohamed Tahir, Mohamed Ibrahim and Ravoof, Thahira B. S. A. and Cowley, Andrew R. and Ali, M. Akbar (2007) Synthesis, characterization and bioactivity of mixed-ligandCu(II) complexes containing Schiff bases derived fromS-benzyldithiocarbazate and saccharinate ligand and the X-raycrystal structure of the copper-saccharinate complex containing S-benzyl-b-N-(Synthesis, characterization and bioactivity of mixed-ligandCu(II) complexes containing Schiff bases derived fromS-benzyldithiocarbazate and saccharinate ligand and the X-raycrystal structure of the copper-saccharinate complex containing S-benzyl-b-N-(acet). Polyhedron, 26 (6). pp. 1159-1165. ISSN 02775387

Abstract / Synopsis

Mixed-ligand complexes of general formula, [Cu(NNS)(sac)] (NNS′ = S-benzyl-β-N-(2-acetylpyrid-2-yl)methylenedithiocarbazate, NNS″ = S-benzyl-β-N-(2-benzoylpyrid-2-yl)methylenedithiocarbazate and NNS‴ = S-benzyl-β-N-(6-methylpyrid-2-yl)methylenedithio-carbazate, sac = the saccharinate anion) have been synthesized by reacting [Cu(sac)2(H2O)4] · 2H2O with the appropriate ligands in ethanol and characterized by various physico-chemical techniques. Magnetic and spectral evidence indicate that the complexes are four-coordinate in which the Schiff bases coordinate as NNS ligands and the sac- anion coordinates as a unidentate N-donor ligand. An X-ray crystallographic structural analysis of [Cu(NNS′)(sac)] shows that the complex has a distorted square-planar geometry with the Schiff base coordinated to the copper (II) ion as a uninegatively charged tridentate chelating agent via the pyridine nitrogen atom, the azomethine nitrogen atom and the thiolate sulphur atom while the fourth coordination position is occupied by the N-bonded saccharinate anion. The complexes have been evaluated for their biological activities against selected pathogens and cancer cell lines. They display weak activity against the pathogenic bacteria and fungi. The complexes were highly active against the leukemic cell line (HL-60) but only [Cu(NNS′)(sac)] was found to exhibit strong cytotoxicity against the ovarian cancer cell line (Caov-3). All complexes were inactive against the breast cancer cell line (MCF-7).


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Additional Metadata

Item Type: Article
Subject: Ligand field theory.
Subject: Solution (Chemistry)
Divisions: Faculty of Science
DOI Number: 10.1016/j.poly.2006.03.007
Publisher: Pergamon Press
Keywords: Copper (II) complexes; Dithiocarbazate Schiff base; Saccharin complexes; S-benzyldithiocarbazate; Tridentate NNS Schiff bases.
Depositing User: Najwani Amir Sariffudin
Date Deposited: 30 Nov 2011 11:17
Last Modified: 24 Nov 2015 12:28
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.poly.2006.03.007
URI: http://psasir.upm.edu.my/id/eprint/17746
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