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Selective in vitro cytotoxic effects of piroxicam and mefenamic acid on several cancer cells lines.


Citation

Somchit, M.N and Ahmad, Zuraini and Hussain, Mohd Khairi and Ab. Hamid, Hasiah and Zakaria, Zainul Amiruddin and S, Faizah (2009) Selective in vitro cytotoxic effects of piroxicam and mefenamic acid on several cancer cells lines. Research Journal of Pharmacology, 3 (1). pp. 15-18. ISSN 1815-9362 / Online ISSN : 1993-6019

Abstract / Synopsis

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are heterogenous group of compounds used to cure and prevent inflammation. It was demonstrated that NSAIDs has the ability to inhibit the viability of colon cancer cells in vitro. We investigated the effects of Piroxicam and mefenamic acid on the viability of 4 cancer cell lines in which 2 of them are colon cancer cell lines (HCT 116 and CaCo-2). Cell viability was determined using MTT assay. Both NSAIDs was observed to markedly decrease the cell viability of both cell lines (HCT 116 and CaCo-2). Piroxicam was statistically more cytotoxic towards the cancer cell lines when compared to mefenamic acid. However, the cytotoxic effect of NSAIDs was less potent on breast cancer cells (MCF-7) and liver cancer cells (Hep G2). In conclusion, piroxicam and mefenamic acid showed selective cytotoxic effects against colon cancer cells but not against liver or breast cancer cells.


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Additional Metadata

Item Type: Article
Subject: Nonsteroidal anti-inflammatory agents.
Subject: Piroxicam.
Subject: Mefenamic acid.
Divisions: Faculty of Medicine and Health Science
Publisher: Medwell Publishing
Keywords: Piroxicam; Mefenamic acid; Cancer; NSAIDs; HCT 116; CaCo-2
Depositing User: Raja Norazlinda Raja Azenam
Date Deposited: 08 Aug 2012 11:22
Last Modified: 08 Aug 2012 11:22
URI: http://psasir.upm.edu.my/id/eprint/17740
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