Association of insertion/deletion polymorphism of angiotensin-converting enzyme gene with essential hypertension and type 2 diabetes mellitus in Malaysian subjects

Vasudevan, Ramachandran and Ismail, Patimah and Stanslas, Johnson and Shamsudin, Norashikin and Moin, Saidi and Mohd Jas, Rusni (2008) Association of insertion/deletion polymorphism of angiotensin-converting enzyme gene with essential hypertension and type 2 diabetes mellitus in Malaysian subjects. Journal of Renin-Angiotensin-Aldosterone System, 9 (4). pp. 208-214. ISSN 1470-3203 & ESSN: 1752-8976

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Abstract

Introduction: The deletion (D) allele of the angiotensin-converting enzyme (ACE) gene has been studied in various populations in relation to hypertension (HTN) and type 2 diabetes mellitus (T2DM) with contradictory results.This study sought to determine the association of insertion (I)/D polymorphism of the ACE gene in hypertensive andT2DM subjects in a Malaysian population. Materials and methods: A total of 260 subjects consisting of 65 HTN, 60 T2DM, 65 T2DM with HTN and 70 controls were recruited. Genotyping was performed by polymerase chain reaction initially and mistyping of DD genotypes was performed with an insertion-specific primer. Results: The frequency for II, ID and DD genotypes of the ACE gene was 36.92%, 52.31% and 10.77% in HTN, 40.00%, 41.67% and 18.33% inT2DM, 30.77%, 53.85% and 15.38% inT2DM with HTN and 57.14%, 40.00% and 2.86% in controls, respectively. The frequency for the D allele was 36.92% in HTN, 39.17% in T2DM and 42.31% in T2DM with HTN compared to 22.86% in controls.The genotype and allele frequency of the ACE gene polymorphism differed significantly in patients when compared to controls (p < 0.05). Conclusion: The D allele of the ACE gene is associated with essential HTN and T2DM in Malaysian subjects.

Item Type:Article
Keyword:Angiotensin-converting enzyme; Essential hypertension; Insertion/deletion polymorphism; Malaysia; Type 2 diabetes mellitus
Subject:Angiotensin-converting enzyme
Subject:Essential hypertension
Subject:Diabetes Mellitus, Type 2 - Malaysia
Faculty or Institute:Faculty of Medicine and Health Science
Publisher:Sage Publications
DOI Number:10.1177/1470320308097499
Altmetrics:http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1177/1470320308097499
ID Code:17687
Deposited By: Raja Norazlinda Raja Azenam
Deposited On:17 Aug 2012 02:57
Last Modified:24 Oct 2012 07:36

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