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Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp.

Cheenpracha, Sarot and Hui, Zhang and Mar, Annie M. N. and Foss, Adam P. and Sek, Hin Foo and Ngit, Shin Lai and Jap, Meng Jee and Heng, Fong Seow and Coy, Choke Ho and Leng, Chee Chang (2009) Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp. Journal of Natural Products, 72 (8). pp. 1520-1523. ISSN 0163-3864 & Online ISSN: 1520-6025

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Official URL: http://pubs.acs.org/toc/jnprdf/72/8

Abstract

Investigation of a microbial fermentation organic extract of Streptomyces sp. H7667 led to the isolation of three new imides, 3-[(5E)-5-methyl-4-oxo-2-hydroxy-5-octenyl glutarimide (1), 2-amino-N-2′-(phenylacetyl)propanimide (5), and 2-amino-N-(2′-(cyclohex-2′′-enyl)acetyl)acetimide (6), and one new isoflavonoid glycoside, 6-O-methyl-7-O-Rrhamnopyranosyldaidzein (7), along with four known compounds. Their structures were elucidated by HRESIMS, 1H and 13C NMR, COSY, HMQC, HMBC, and NOESY spectra. Compounds 1-8 were evaluated for their inhibitory activities in the yeast glycogen synthase kinase-3 assay.

Item Type:Article
Subject:Glycogen synthase kinase-3.
Subject:Streptomyces.
Faculty or Institute:Faculty of Medicine and Health Science
Publisher:American Society of Pharmacognosy & American Chemical Society
DOI Number: 10.1021/np900163f
Altmetrics:http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1021/np900163f
ID Code:17669
Deposited By: Raja Norazlinda Raja Azenam
Deposited On:17 Aug 2012 12:21
Last Modified:17 Aug 2012 12:21

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