Distribution of CBP genes in Streptococcus pneumoniae isolates in relation to vaccine types, penicillin susceptibility and clinical site.

Citation

Mohd Desa, Mohd Nasir and Sekaran, Shamala Devi and Vadivelu, Jamunarani and Navaratnam, Parasakthi (2008) Distribution of CBP genes in Streptococcus pneumoniae isolates in relation to vaccine types, penicillin susceptibility and clinical site. Epidemiology and Infection, 136 (7). pp. 940-942. ISSN 0950-2688; ESSN: 1469-4409

Abstract

Choline-binding proteins (CBP) have been associated with the pathogenesis of Streptococcus pneumoniae. We screened, using PCR, for the presence of genes (cbpA, D, E, G) encoding these proteins in 34 isolates of pneumococci of known serotypes and penicillin susceptibility from invasive and non-invasive disease. All isolates harboured cbpD and cbpE whereas cbpA and cbpG were found in 47% and 59% respectively; the latter were more frequent in vaccine-associated types and together accounted for 77% of these isolates. No association was observed with penicillin susceptibility but 85% of non-invasive isolates were positive for these genes.

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Additional Metadata

Item Type:	Article
Divisions:	Faculty of Medicine and Health Science
DOI Number:	https://doi.org/10.1017/S0950268807009363
Publisher:	Cambridge University Press
Keywords:	Choline-binding proteins (CBP); Streptococcus pneumoniae; Penicillins; Pneumococcal vaccines; Genes.
Depositing User:	Raja Norazlinda Raja Azenam
Date Deposited:	07 Mar 2014 04:55
Last Modified:	23 Oct 2015 06:45
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1017/S0950268807009363
URI:	http://psasir.upm.edu.my/id/eprint/14107
Statistic Details:	View Download Statistic

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