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Wnt Signaling Pathway Related Genes In Hepatocellular Carcinoma

Ban, Kechen (2002) Wnt Signaling Pathway Related Genes In Hepatocellular Carcinoma. PhD thesis, Universiti Putra Malaysia.

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Abstract

Hepatocellular carcinoma (HCC) is an extremely difficult disease to manage and one of the ten most common cancers in Malaysia. However, the molecular mechanisms that contribute to tumour progression in hepatocarcinogenesis remain unknown. In recent years, the evidence that the Wnt signaling pathway may play a crucial role in the hepatocarcinogenesis represents a major breakthrough. Despite efforts made in this area of research, the relationship between the related genes of Wnt signaling pathway is still far from comprehensive. By employing immunohistochemistry and DNA sequencing, some related proteins and genes of the Wnt signaling pathway were investigated in 23 paired HCC and adjacent liver specimens from a tertiary referral centre in Malaysia.

Item Type:Thesis (PhD)
Chairman Supervisor:Associate Professor Dr. Seow Heng Fong
Call Number:FPSK(P) 2002 1
Faculty or Institute:Faculty of Medicine and Health Science
ID Code:11271
Deposited By: Mohd Nezeri Mohamad
Deposited On:18 Jul 2011 10:07
Last Modified:08 Aug 2011 12:43

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