Toxic Effects Of Signal Grass (Brachiaria Decumbens) On Drug- Metabolizing Enzyme Activities In Sheep

Hussain, Mohd Khairi (2003) Toxic Effects Of Signal Grass (Brachiaria Decumbens) On Drug- Metabolizing Enzyme Activities In Sheep. Masters thesis, Universiti Putra Malaysia.

[img] PDF
1008Kb

Abstract

Signal grass (Brachiaria decumbens) is widely grown on livestock farms in many countries including Malaysia due to its high productivity and nutritive value. Unfortunately, it is toxic to sheep and goats causing a severe hepatic and renal damage, and death. Two experiments were conducted to determine the effect of the toxicity of signal grass (B. decumbens) on the activity of drug-metabolizing enzymes (DME) in sheep and cattle. It was hypothesized that the activities of selected enzymes would be affected during intoxication and that differences in the activity level of the enzymes in the two species might explain why cattle were safe from the toxic effect of the grass. Twenty-three healthy Wiltshire-Malin crossed rams, aged 1 4- 1 6 months were used, fifteen for the first experiment and eight for the later. In the first experiment, aniline 4-hydroxylase (A4H), aminopyrine N-demethylase (AND), UDP-glucuronyl transferase (UDPGT), glutathione S-transferase (GST) and cytochrome P450 of the liver and kidney of the control and intoxicated sheep were

Item Type:Thesis (Masters)
Chairman Supervisor:Professor Dato' Abdul Salam Abdullah, PhD
Call Number:FPSK(M) 2003 15
Faculty or Institute:Faculty of Medicine and Health Science
ID Code:11261
Deposited By: Mohd Nezeri Mohamad
Deposited On:18 Jul 2011 02:18
Last Modified:08 Aug 2011 04:53

Repository Staff Only: Edit item detail

Document Download Statistics

This item has been downloaded for since 18 Jul 2011 02:18.

View statistics for "Toxic Effects Of Signal Grass (Brachiaria Decumbens) On Drug- Metabolizing Enzyme Activities In Sheep "


Universiti Putra Malaysia Institutional Repository

Universiti Putra Malaysia Institutional Repository is an on-line digital archive that serves as a central collection and storage of scientific information and research at the Universiti Putra Malaysia.

Currently, the collections deposited in the IR consists of Master and PhD theses, Master and PhD Project Report, Journal Articles, Journal Bulletins, Conference Papers, UPM News, Newspaper Cuttings, Patents and Inaugural Lectures.

As the policy of the university does not permit users to view thesis in full text, access is only given to the first 24 pages only.