Roles Of Transforming Growth Factor-Beta, Insulin-Like Growth Factors And Proteases In Human Breast Cancer

Wong, Shew Fung (2002) Roles Of Transforming Growth Factor-Beta, Insulin-Like Growth Factors And Proteases In Human Breast Cancer. Masters thesis, Universiti Pertanian Malaysia.

[img] PDF
876Kb

Abstract

Transforming growth factor-beta (TGF) is present in breast cysts, normal and cancerous breast tissue. It plays an important role in oestrogen metabolism. However, TGF is present predominantly in latent form and the mechanisms by which latent TGF is activated physiologically remain largely an enigma. The aims of this study were: 1) to investigate the effects of TGF B' IGF-I and IGF-II on cell growth, E1STS and E2DH activities in the hormone-dependent MCF-7 and honnone-independent MDA-MB-231 human breast cancer cell lines. 2) to investigate the effect of Cathepsin D and PSA on TGFl and TGF2 mRNA expression, and their protein levels in both of the cell lines. 3) to study the effect of Cathepsin D and PSA on Type 1 and Type 2 E2DH mRNA expression, EJ and E2 levels in both cell lines.

Item Type:Thesis (Masters)
Call Number:FPSK(M) 2002 6
Faculty or Institute:Faculty of Medicine and Health Science
ID Code:11240
Deposited By: Mohd Nezeri Mohamad
Deposited On:18 Jul 2011 03:19
Last Modified:10 Aug 2011 06:13

Repository Staff Only: Edit item detail

Document Download Statistics

This item has been downloaded for since 18 Jul 2011 03:19.

View statistics for "Roles Of Transforming Growth Factor-Beta, Insulin-Like Growth Factors And Proteases In Human Breast Cancer "


Universiti Putra Malaysia Institutional Repository

Universiti Putra Malaysia Institutional Repository is an on-line digital archive that serves as a central collection and storage of scientific information and research at the Universiti Putra Malaysia.

Currently, the collections deposited in the IR consists of Master and PhD theses, Master and PhD Project Report, Journal Articles, Journal Bulletins, Conference Papers, UPM News, Newspaper Cuttings, Patents and Inaugural Lectures.

As the policy of the university does not permit users to view thesis in full text, access is only given to the first 24 pages only.