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Potential of 3'-fluoro-3' deoxythymidine as a cellular proliferation marker in PET oncology examination

Hassan, Hishar and Price, Roger and Ahmad Saad, Fathinul Fikri and Lau, Eddie Wing Fai and Carpinelli, Assunta and Nordin, Abdul Jalil (2016) Potential of 3'-fluoro-3' deoxythymidine as a cellular proliferation marker in PET oncology examination. Pertanika Journal of Science & Technology, 24 (1). pp. 41-52. ISSN 0128-7680; ESSN: 2231-8526

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Official URL: http://www.pertanika.upm.edu.my/Pertanika%20PAPERS...

Abstract

Development of the positron emission tomography (PET) diagnostic radiopharmaceutical (18F) fluoro-2-deoxy-D-glucose (18F-FDG) subsequently facilitated the discovery and clinical evaluation of several new tracers as imaging markers for cancer. While 18F-FDG is a widely employed marker forenhanced intracellular glycolysis and metabolic function, one of the newer tracers, (18F)-3'-fluoro-3'deoxythymidine (18F-FLT), has been developed as a biomarker for cell proliferation. In this review, the potential of 18F-FLT as a biomarker for cancer imaging is discussed.

Item Type:Article
Keyword:18F-FLT; 18F-FDG; Positron emission tomography (PET); Cellular proliferation
Faculty or Institute:Faculty of Medicine and Health Science
Publisher:Universiti Putra Malaysia Press
ID Code:10582
Deposited By: Nabilah Mustapa
Deposited On:15 Mar 2011 19:50
Last Modified:26 Jan 2016 14:09

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