Citation
Jarrar, Qais Bashir Mahmoud and Ahmad, Zuraini and Abdul Kadir, Arifah and Zakaria, Zainul Amiruddin and Abdullah, Muhammad Nazrul Hakim
(2017)
Liposome encapsulation: a promising approach to enhanced and safe mefenamic acid therapy.
International Research Journal of Education and Sciences, 1 (1).
pp. 32-39.
ISSN 2550-2158
Abstract
Mefenamic acid (MEF) is a non-steroidal anti-inflammatory drug (NSAID) characterized by low bioavailability with relative high toxicity. Despite the efforts which have been paid to enhance its bioavailability, its inherent toxicity remains the limiting factor for its medical uses. Designing MFE as a prodrug of ester derivatives can attenuate gastrointestinal (GI) toxicity, but shows no advantages in term of therapeutic efficacy. Liposomes have a dual action and would be a promising tool to enhance MFE bioavailability and reduce its gastric and systemic adverse reactions. This review covers the pharmacological and toxicological aspects of MFE and provides substantial trend to enhance its clinical therapy.
Download File
Official URL or Download Paper: http://www.masree.info/journal/irjes/2017-vol-1-is...
|
Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Medicine and Health Science Faculty of Veterinary Medicine Halal Products Research Institute Sport Academy |
| Publisher: | Malaysia Association of Research and Education for Educators |
| Keywords: | Bioavailability; Mefenamic acid; Proliposome; Phospholipids; Toxicity |
| Depositing User: | Nabilah Mustapa |
| Date Deposited: | 01 Mar 2018 02:46 |
| Last Modified: | 01 Mar 2018 02:46 |
| URI: | http://psasir.upm.edu.my/id/eprint/59391 |
| Statistic Details: | View Download Statistic |
Actions (login required)
 |
View Item |