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Stability analysis of closed-loop anaesthesia system with nonlinear uncertainty: a circle criterion approach


Citation

Chang, Jing Jing and Syam, Syafiie (2016) Stability analysis of closed-loop anaesthesia system with nonlinear uncertainty: a circle criterion approach. In: 2016 IEEE-EMBS Conference on Biomedical Engineering and Sciences (IECBES), 4-8 Dec. 2016, Kuala Lumpur, Malaysia. (pp. 664-668).

Abstract

Inter-individual variability is one of the major challenge in closed-loop control of anaesthesia. This variability could lead to stability problem and must be taken into account during the evaluation of controller. While studies have suggested that variability in nonlinear pharmacodynamics (PD) model is much higher than the linear pharmacokinetic (PK) model, most of the robust stability analyses have only considered uncertainty that exists linearly. In this study, robust stability analysis of a closed-loop anaesthesia control system on uncertainty in nonlinearity was performed. The closed-loop control system consists of a PKPD model and a PID controller that was treated as a Lur'e problem. Circle criterion was applied to determine the bound of nonlinearity that guarantees asymptotic stability of the system. Result shows that the stability bound of the controller is sufficiently large for the possible inter-variability in non-linearity among patients.


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Additional Metadata

Item Type: Conference or Workshop Item (Paper)
Divisions: Faculty of Engineering
DOI Number: https://doi.org/10.1109/IECBES.2016.7843533
Publisher: IEEE
Keywords: Absolute stability; Depth of anaesthesia; Model uncertainty; Nonlinearity; PKPD model
Depositing User: Nabilah Mustapa
Date Deposited: 30 Jun 2017 09:54
Last Modified: 30 Jun 2017 09:54
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1109/IECBES.2016.7843533
URI: http://psasir.upm.edu.my/id/eprint/55926
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