Citation
Abstract
Our recent research on the phytochemical constituents of the stem bark of Mesua beccariana gave one new xanthone, beccarixanthone T (1) and one new coumarin, beccamarin T (2) together with three known xanthones mesuarianone (3), mesuasinone (4), 1,5-dihydroxyxanthone (5) and four known terpenoids, friedelin (6), stigmasterol (7), beta-sitosterol (8) and gamma-sitosterol (9). The structures of these compounds were elucidated and determined using spectroscopic techniques such as NMR and MS. The cytotoxic activities of compounds 1-4 as well as the crude extracts were tested against two cancer cell lines, Hep G2 (liver cancer cell line) and HT-29 (colon cancer cell line) using MTT assays. Mesuarianone (3) gave a significant activity on the HT-29 cell line while mesuasinone (4) gave moderate activity against HT-29 cell line.
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Science Institute of Bioscience |
| DOI Number: | https://doi.org/10.1016/j.phytol.2016.07.026 |
| Publisher: | Elsevier |
| Keywords: | Mesua beccariana; Coumarin; Xanthone; Cytotoxic |
| Depositing User: | Mohd Hafiz Che Mahasan |
| Date Deposited: | 02 Oct 2017 06:23 |
| Last Modified: | 02 Oct 2017 06:23 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.phytol.2016.07.026 |
| URI: | http://psasir.upm.edu.my/id/eprint/55415 |
| Statistic Details: | View Download Statistic |
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