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Cytokines (IL 1β and IL 6) responses in non-pregnant does infected with corynebacterium pseudotuberculosis following intradermal route of infection in chronic state


Citation

Abdullah, Faez Firdaus Jesse and Abdul Latif, Nur-Amirah and Lim, Eric Teik Chung and Adamu, Lawan and Sarah, Siti Aimi and Zamri-Saad, Mohd and Haron, Abdul Wahid and Mohd Lila, Mohd Azmi and Zakaria, Zunita (2016) Cytokines (IL 1β and IL 6) responses in non-pregnant does infected with corynebacterium pseudotuberculosis following intradermal route of infection in chronic state. International Journal of Livestock Research, 6 (6). pp. 1-8. ISSN 2277-1964

Abstract / Synopsis

Corynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis (CLA) which commonly affects sheep and goats. The disease remains as a major disease causing economic loss to the small ruminant industries. There is little information related to responses of interleukin-1β and interleukin-6 in the chronic states. This study was designed to determine the serum concentrations of interleukin-1β and interleukin-6 (pg/mL) in non-pregnant does experimentally inoculated with Corynebacterium pseudotuberculosis via intradermal route in chronic form. Eighteen non-pregnant healthy Katjang does aged 2 years old were divided randomly into two groups. The control and the treatment groups consist of nine does each and were kept for 3 months. The control group was inoculated with PBS solution while the treatment group was inoculated intradermally with C. pseudotuberculosis. Serum samples were collected every 3 days (72 hours) for 3 months (2064 hours). The present study showed significant increase in IL-1β (278 ± 19.19 pg/mL) after 1day (24 hours) of post infection (p<0.0001) which decreased sharply (98.31 ± 19.19 pg/mL) after 5 days (120 hours) of post infection (p = 0.9293) and attained a significant concentration (217.43 ± 19.19 pg/mL) after 3 months (2064 hours) of post infection (p<0.0048) in does challenged with C. pseudotuberculosis compared to the control group. In contrast, the concentration of IL-6 increased significantly (p<0.0001) to (56.43 ± 1.98 pg/mL) in 2 months (1392 hours) of post infection and then decreased significantly (p<0.0001) to concentration of (22.18 ± 1.98 pg/mL) in 3 months (2064 hours) compared to the control group. In conclusion, the present study indicate that the importunity of C. pseudotuberculosis is associated with persistently high concentrations of IL-1β and low concentration of IL-6 which, when interpreted, could severely contribute to pathological vicissitudes and injury of organs and tissues in the chronic stage of C. pseudotuberculosis infections.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
DOI Number: 10.5455/ijlr.20160613104909
Publisher: Pashupati Foundation India
Keywords: Corynebacterium pseudotuberculosis; Chronic form; Interleukin-1β; Interleukin-6; Non-Pregnant does; Intradermal route
Depositing User: Mohd Hafiz Che Mahasan
Date Deposited: 16 Nov 2017 19:30
Last Modified: 16 Nov 2017 19:30
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.5455/ijlr.20160613104909
URI: http://psasir.upm.edu.my/id/eprint/55413
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