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Cryptotanshinone inhibits TNF-α-induced early atherogenic events in vitro

Ahmad, Zuraini and Chin, Theng Ng and Lai, Yen Fong and Abu Bakar, Nurul Ain and Mohd Hussain, Nor Hayuti and Kok, Pian Ang and Cheng , Gwendoline Lian Ee and , Muhammad Nazrul Hakim (2016) Cryptotanshinone inhibits TNF-α-induced early atherogenic events in vitro. The Journal of Physiological Sciences, 66 (3). pp. 213-220. ISSN 1880-6546

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Abstract

Endothelial dysfunction has been implicated in the pathogenesis of atherosclerosis. Salvia miltiorrhiza (danshen) is a traditional Chinese medicine that has been effectively used to treat cardiovascular disease. Cryptotanshinone (CTS), a major lipophilic compound isolated from S. miltiorrhiza, has been reported to possess cardioprotective effects. However, the anti-atherogenic effects of CTS, particularly on tumor necrosis factor-α (TNF-α)-induced endothelial cell activation, are still unclear. This study aimed to determine the effect of CTS on TNF-α-induced increased endothelial permeability, monocyte adhesion, soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), monocyte chemoattractant protein 1 (MCP-1) and impaired nitric oxide production in human umbilical vein endothelial cells (HUVECs), all of which are early events occurring in atherogenesis. We showed that CTS significantly suppressed TNF-α-induced increased endothelial permeability, monocyte adhesion, sICAM-1, sVCAM-1 and MCP-1, and restored nitric oxide production. These observations suggest that CTS possesses anti-inflammatory properties and could be a promising treatment for the prevention of cytokine-induced early atherogenesis.

Item Type:Article
Keyword:Cryptotanshinone; Nitric oxide; Soluble cellular adhesion molecule; TNF-α; Monocyte adhesion; Chemokine
Publisher:Springer
DOI Number:10.1007/s12576-015-0410-7
Altmetrics:http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1007/s12576-015-0410-7
ID Code:55402
Deposited By: Mohd Hafiz Che Mahasan
Deposited On:02 Oct 2017 17:20
Last Modified:02 Oct 2017 17:20

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