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Emulsion formulation optimization and characterization of spray-dried k-carrageenan micropeprintss for the encapsulation of CoQ10


Citation

Chan, Sook Wah and Mirhosseini, Hamed and Taip, Farah Saleena and Ling, Tau Chuan and Nehdi, Imededdine Arbi and Tan, Chin Ping (2016) Emulsion formulation optimization and characterization of spray-dried k-carrageenan micropeprintss for the encapsulation of CoQ10. Food Science and Biotechnology, 25 (suppl. 1). pp. 53-62. ISSN 1226-7708; ESSN: 2092-6456

Abstract

The present study is aimed to prepare κ-carrageenan microparticles for the encapsulation of model drug, coenzyme Q10 (CoQ10). A face-centered central composite design was employed to study the effects of three different formulation variables (κ-carrageenan, emulsifier, and oil). The powder yield was found inversely affected by the κ-carrageenan and oil concentration. The encapsulation efficiency was maximized in the region of the middle level κ-carrageenan concentration, the high level emulsifier concentration, and the low level oil concentration. The emulsifier concentration was the most influential variable on the particle size of powder. The optimal formulation was reported as 0.91% (w/v) κ-carrageenan concentration, 0.64% (w/v) emulsifier, and 1.0% (w/w) oil. Both differential scanning colorimeter and X-ray diffraction analyses proved that incorporation of CoQ10 into κ- carrageenan microcapsules resulted in amorphous powder with significantly (p<0.05) higher water solubility compared to pure CoQ10 and physical mixture in the crystalline form.


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Additional Metadata

Item Type: Article
Subject: κ-carrageenan; Coenzyme Q10; Spray drying; Emulsion formulation; Water solubility
Divisions: Faculty of Engineering
Faculty of Food Science and Technology
DOI Number: https://doi.org/10.1007/s10068-016-0098-3
Publisher: Korean Society of Food Science and Technology
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 01 Mar 2018 04:46
Last Modified: 01 Mar 2018 04:46
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1007/s10068-016-0098-3
URI: http://psasir.upm.edu.my/id/eprint/54152
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