Citation
Juhan, Siti Fadilah and Md Sukari, Mohd Aspollah and Syed Abdul Azziz, Saripah Salbiah and Wong, Chee Fah and Alimon, Hasimah and Mohd Nor, Siti Mariam
(2016)
New synthesised aminoanthraquinone derivatives and its antimicrobial and anticancer activities (route II).
International Journal of Contemporary Applied Sciences, 3 (1).
pp. 18-33.
ISSN 2308-1365
Abstract
A series of aminoanthraquinone derivatives were synthesized via two reaction steps. The starting material of 1,4-dihydroxyanthraquinone (1) was subjected toamination and the major product obtained was then further reacted under reduction, methylation and acylation separately to produce 2-(butylamino)anthracene-1,4-dione (2), 2-(butylamino)-1-hydroxy-4-methoxyanthracene-9,10-dione (9), 2-(butylamino)-1,4-dimethoxyanthracene-9,10-dione (10), 3-(butylamino)-4-hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-yl-acetate (11), 2-(butylamino)-4-hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-yl-acetate (12) and 2-(butylamino)-9,10-dioxo-9,10-dihydroanthracene-1-yl-acetate (13). Aminoanthraquinone13 exhibitedstrong antimicrobial activities toward Methicillin-Resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, Candida albicans and Escherichia coli with MIC values of 0.1, 0.1, 0.1 and 0.5 mg/mL respectively. Aminoanthraquinones 9, 10 and 13 showed strong cytotoxicity against both MCF-7 (IC50 2.0-11.0μg/mL)and Hep-G2 (IC50 1.1-14.0μg/mL) cell lines.
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