Citation
Abstract
A study was conducted to investigate the effect of Centella asiatica extract and powder on dietary intake, body weight, organ weights and blood lipid peroxidation of hydrogen peroxide (H2O2)-treated male Sprague-Dawley rats. The experimental rats were fed with 0.3% (w/w) C. asiatica extract, 1.5% (w/w) C. asiatica powder, 5.0% (w/w) C. asiatica powder and 0.3% (w/w) a-tocopherol for 6 weeks. To induce oxidative stress, the rats were given drinking water spiked with 0.03% (v/v) H2O2. The amount of dietary intake, organ and body weight, and malonaldehyde (MDA) level throughout the study were monitored. Histopathological examination of selected organs was done at the end of the study. The results showed that MDA level was significantly (p <0.05) higher in the normal rats compared to treated rats. Dietary supplementation of C. asiatica (extract and powder) and a-tocopherol significantly (p <0.05) reduced lipid peroxidation in the experimental rats. However, there were no significant differences in dietary intake and histopathology observations of the organs of the rats.
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Food Science and Technology Faculty of Veterinary Medicine Institute of Bioscience |
| Publisher: | Malaysian Agricultural Research and Development Institute (MARDI) |
| Keywords: | Centella asiatica; Lipid peroxidation; Malonaldehyde; Hydrogen peroxide; Sprague-Dawley rats |
| Depositing User: | Nabilah Mustapa |
| Date Deposited: | 29 Dec 2016 09:34 |
| Last Modified: | 29 Dec 2016 09:34 |
| URI: | http://psasir.upm.edu.my/id/eprint/48884 |
| Statistic Details: | View Download Statistic |
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