Citation
Wahyuni, Fatma Sri and Stanslas, Johnson and Lajis, Nordin and Hamidi, Dachriyanus
(2015)
Cytotoxicity studies of tetraprelyltoluquinone, a prenilated hydroquinone from Garcina cowa Roxb on H-460, MCF-7 and DU-145.
International Journal of Pharmacy and Pharmaceutical Sciences, 7 (3).
pp. 60-63.
ISSN 0975-1491
Abstract
Objective: The aim of the present study was to examine the cytotoxicity of a new ring-reduced tetra prenyltoluquinone (TPTQ), [2E,6E,10E]-(+)-4b-hydroxy-3-methyl-5b-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl-2-cyclohexen-1-one against H-460, MCF-7 and DU-145 cell lines. Methods: Different concentrations of TPTQ were subjected to cytotoxicity study by using MTT method and calculate the percentage of cell viability. Results: The results of this study showed that this compound has IC50 value 16.3 ± 3.0 µM in H-460 cancer cell lines without any activities towards another two type of cell lines. Conclusion: TPTQ had selective activity against H-460 cancer cell lines.
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Medicine and Health Science Institute of Bioscience |
| Publisher: | Innovare Academic Sciences |
| Keywords: | Garcinia cowa; TPTQ; H-460; MCF-7; DU-145; Cell viability; Cytotoxicity |
| Depositing User: | Nurul Ainie Mokhtar |
| Date Deposited: | 17 Jan 2018 03:34 |
| Last Modified: | 17 Jan 2018 03:34 |
| URI: | http://psasir.upm.edu.my/id/eprint/44233 |
| Statistic Details: | View Download Statistic |
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