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Assessing respiratory inflammation among children living near to non-sanitary landfill using interleukin-6 (IL-6)


Citation

Syed Ismail, Sharifah Norkhadijah and Othman, Muhammad S. and Jamaluddin, Dora E. and Praveena, Sarva Mangala and Ho, Yu Bin and Zainal Abidin, Emilia and A. Wahab, Aini Syuhaida and A., Haryati (2015) Assessing respiratory inflammation among children living near to non-sanitary landfill using interleukin-6 (IL-6). Advances in Research, 3 (4). pp. 404-416. ISSN 2348-0394

Abstract

Aims: To determine the respiratory inflammation among children living near to non-sanitary municipal solid waste landfill area and the concentration of Interleukin-6 cytokine. Study Design: A cross-sectional comparative study design. Place and Duration of Study: Sample: Pajam, Negeri Sembilan, Malaysia, between September 2013 and April 2014. Methodology: A total of 72 children were randomly selected based on the inclusive and exclusive criteria. A set of pre-tested questionnaires were utilized to obtain socio-demographic information and to predict health risk faced by the respondents. Saliva samples of the respondents were collected and analyzed using Human Interleukin-6 (IL-6) Platinum ELISA (Enzyme-Linked Immunosorbent Assay) kit. Results: The PM10 concentration for the exposed group was higher than the unexposed group with the mean ± standard deviation (SD) of 152.31±31.07 μg/m3 and 87.77±30.77 μg/m3 respectively. The mean ± SD of the Interleukin-6 for the exposed group was slightly higher than the unexposed group with the mean ± SD of 6.34±1.95 pg/ml and 5.77±1.08 pg/ml respectively. The most common symptoms reported was sneezing and sore throat. There was no significant correlation between PM10 concentration and IL-6 in this study. Conclusion: The findings exhibit that there was no association between Interleukin-6 and PM10 concentration of the respondent. However, there are likely potential adverse health impacts arising from particulates exposure among exposed children in this study. Respondents are advised to have a medical check-up in order to determine respiratory health status thus elimination the risks of acquiring respiratory inflammation.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.9734/AIR/2015/14478
Publisher: SCIENCEDOMAIN International
Keywords: Respiratory inflammation; Children; Landfill; Saliva; Interleukin-6
Depositing User: Mohd Hafiz Che Mahasan
Date Deposited: 26 Oct 2016 08:44
Last Modified: 26 Oct 2016 08:44
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.9734/AIR/2015/14478
URI: http://psasir.upm.edu.my/id/eprint/43844
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