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Subclinical hypothyroidism among patients with depressive disorders


Citation

Zahari Sham, Siti Yazmin and Umar, Nor Aini and Hambali, Zarida and Razali, Rosdinom and Abdul Manaf, Mohd Rizal (2014) Subclinical hypothyroidism among patients with depressive disorders. Malaysian Journal of Medicine and Health Sciences, 10 (2). pp. 71-78. ISSN 1675-8544

Abstract

Subclinical hypothyroidism (SHT) is a biochemical diagnosis, defined as an elevated Thyroid Stimulating Hormone (TSH) with normal free thyroxine (FT4). It affects 4-10% of the adult population and is more prevalent in elderly women. Its commonest cause is autoimmune thyroiditis, detected by anti-thyroid peroxidase antibody (TPO-Ab). About 2-5% of SHT patients progress to overt hypothyroidism annually. The SHT prevalence among depressed patients ranges between 3% and 17%. This study aimed to determine the prevalence of SHT and TPO-Ab positivity among patients diagnosed with depressive disorders. It was a cross-sectional study carried out in the Universiti Kebangsaan Malaysia Medical Centre over a 12 months period. Serum TSH, FT4 and TPO-Ab were measured. Results showed that 82% of depressed patients were euthyroid, 4% had SHT, 11% had subclinical hyperthyroidism and 2% had discordant thyroid function. TPO-Ab positivity among the subjects was 7%, one of whom had SHT. In conclusion, the prevalence of SHT and TPO-Ab positivity in the study population, at 4% and 7%, respectively, were comparable to previous findings.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
Keywords: Subclinical hypothyroid; Prevalence; Depressed patients; Anti-thyroid peroxidase antibody
Depositing User: Mohd Hafiz Che Mahasan
Date Deposited: 18 Dec 2015 04:23
Last Modified: 18 Dec 2015 04:23
URI: http://psasir.upm.edu.my/id/eprint/41424
Statistic Details: View Download Statistic

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