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Antimicrobial, antioxidant, antitumour-promoting and cytotoxic activities of different plant part extracts of Garcinia atroviridis Griff. ex T. Anders


Citation

Mohamed Mackeen, Muhammad Mukram and Ali, Abdul Manaf and Lajis, Nordin and Kawazu, Kazuyoshi and Hassan, Zaiton and Amran, Mugahed and Mohamad, Habsah and Mooi, Lim Yang and Mohamed, S. M. (2000) Antimicrobial, antioxidant, antitumour-promoting and cytotoxic activities of different plant part extracts of Garcinia atroviridis Griff. ex T. Anders. Journal of Ethnopharmacology, 72 (3). pp. 395-402. ISSN 0378-8741; ESSN: 1872-7573

Abstract

Crude extracts (methanol) of various parts, viz. the leaves, fruits, roots, stem and trunk bark, of Garcinia atroviridis were screened for antimicrobial, cytotoxic, brine shrimp toxic, antitumour-promoting and antioxidant activities. The crude extracts exhibited predominantly antibacterial activity with the root extract showing the strongest inhibition against the test bacteria at a minimum inhibitory dose (MID) of 15.6 μg/disc. Although all the extracts failed to inhibit the growth of most of the test fungi, significant antifungal activity against Cladosporium herbarum was exhibited by most notably the fruit (MID: 100 μg), and the leaf (MID: 400 μg) extracts. None of the extracts were significantly cytotoxic, and lethal towards brine shrimps. The root, leaf, trunk and stem bark extracts (except for the fruits) showed strong antioxidant activity exceeding that of the standard antioxidant, α-tocopherol. Antitumour-promoting activity (>95% inhibition) was shown by the fruit, leaf, stem and trunk bark extracts.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Faculty of Food Science and Technology
Faculty of Science
DOI Number: https://doi.org/10.1016/S0378-8741(00)00245-2
Publisher: Elsevier
Keywords: Garcinia atroviridis; Antimicrobial; Antioxidant; Antitumour-promoting
Depositing User: Nabilah Mustapa
Date Deposited: 17 Sep 2015 00:57
Last Modified: 17 Sep 2015 00:57
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/S0378-8741(00)00245-2
URI: http://psasir.upm.edu.my/id/eprint/40314
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