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Exploring cancer development in adulthood: cholinesterase depression and genotoxic effect from chronic exposure to organophosphate pesticides among rural farm children


Citation

How, Vivien and Hashim, Zailina and Ismail, Patimah and Md Said, Salmiah and Omar, Dzolkhifli and Mohd Tamrin, Shamsul Bahri (2014) Exploring cancer development in adulthood: cholinesterase depression and genotoxic effect from chronic exposure to organophosphate pesticides among rural farm children. Journal of Agromedicine, 19 (1). pp. 35-43. ISSN 1059-924X; ESSN: 1545-0813

Abstract

Children are the vulnerable group in the agricultural community due to their early exposure to pesticides through the dynamic interplay between genetic predisposition, environment, and host-related factors. This study aims to identify the possible association between the depression in blood cholinesterase level and genotoxic effect among farm children. The results of micronuclei assay and comet assay showed that the reduced blood cholinesterase level from organophosphate pesticide exposure is significantly associated with an increase in chromosome breakage and DNA strand breaks. These genotoxicity end points suggest that farm children's cells experience early DNA damage that may lead to uncontrolled cell proliferation during their adulthood. Thus, farm children who grow up near pesticide-treated farmland have a higher probability of developing cancer than children with minimal or zero exposure to pesticides.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Agriculture
Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1080/1059924X.2013.866917
Publisher: Taylor & Francis
Keywords: Children; Cholinesterase depression; Genotoxicity risk; Organophosphate
Depositing User: Nabilah Mustapa
Date Deposited: 22 Apr 2016 03:29
Last Modified: 22 Apr 2016 03:29
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1080/1059924X.2013.866917
URI: http://psasir.upm.edu.my/id/eprint/37566
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