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Chemoenzymatic epoxidation of alkenes and reusability study of the phenylacetic acid

Abd. Malek, Emilia and Arumugam, Mahashanon and Mizan, Hanis Nabillah and Abdul Rahman, Mohd Basyaruddin and Basri, Mahiran and Salleh, Abu Bakar (2014) Chemoenzymatic epoxidation of alkenes and reusability study of the phenylacetic acid. The Scientific World Journal, 2014 . art. no. 756418. pp. 1-7. ISSN 2356-6140; ESSN: 1537-744X

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Official URL: http://www.hindawi.com/journals/tswj/2014/756418/

Abstract

Here, we focused on a simple enzymatic epoxidation of alkenes using lipase and phenylacetic acid. The immobilised Candida antarctica lipase B, Novozym 435 was used to catalyse the formation of peroxy acid instantly from hydrogen peroxide (H2O2) and phenylacetic acid. The peroxy phenylacetic acid generated was then utilised directly for in situ oxidation of alkenes. A variety of alkenes were oxidised with this system, resulting in 75–99% yield of the respective epoxides. On the other hand, the phenylacetic acid was recovered from the reaction media and reused for more epoxidation. Interestingly, the waste phenylacetic acid had the ability to be reused for epoxidation of the 1-nonene to 1-nonene oxide, giving an excellent yield of 90%.

Item Type:Article
Keyword:Enzymatic epoxidation; Alkenes; Phenylacetic acid
Faculty or Institute:Faculty of Biotechnology and Biomolecular Sciences
Faculty of Science
Publisher:Hindawi Publishing Corporation
DOI Number:10.1155/2014/756418
Altmetrics:http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2014/756418
ID Code:36777
Deposited By: Nabilah Mustapa
Deposited On:05 Aug 2015 11:48
Last Modified:27 Aug 2015 10:08

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