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Assessment of antioxidant and cytotoxicity activities of saponin and crude extracts of Chlorophytum borivilianum

Ashraf, Mehdi Farshad and Abdul Aziz, Maheran and Stanslas, Johnson and Ismail, Ismanizan and Abdul Kadir, Mihdzar (2013) Assessment of antioxidant and cytotoxicity activities of saponin and crude extracts of Chlorophytum borivilianum. The Scientific World Journal, 2013 . art. no. 216894. pp. 1-7. ISSN 2356-6140; ESSN: 1537-744X

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Abstract

The present paper focused on antioxidant and cytotoxicity assessment of crude and total saponin fraction of Chlorophytum borivilianum as an important medicinal plant. In this study, three different antioxidant activities (2,2-diphenyl-1-picrylhydrazyl radical scavenging (DPPH), ferrous ion chelating (FIC), and β-carotene bleaching (BCB) activity) of crude extract and total saponin fraction of C. borivilianum tubers were performed. Crude extract was found to possess higher free radical scavenging activity (ascorbic acid equivalents 2578 ± 111 mg AA/100 g) and bleaching activity (IC50 = 0.7 mg mL−1), while total saponin fraction displayed higher ferrous ion chelating (EC50 = 1 mg mL−1). Cytotoxicity evaluation of crude extract and total saponin fraction against MCF-7, PC3, and HCT-116 cancer cell lines using 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) cell viability assay indicated a higher cytotoxicity activity of the crude extract than the total saponin fraction on all cell lines, being most effective and selective on MCF-7 human breast cancer cell line.

Item Type:Article
Keyword:Chlorophytum borivilianum; Antioxidant activities; Cytotoxicity assessment of crude; Total saponin fraction
Faculty or Institute:Faculty of Agriculture
Faculty of Medicine and Health Science
Institute of Tropical Agriculture
Publisher:Hindawi Publishing Corporation
DOI Number:10.1155/2013/216894
Altmetrics:http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2013/216894
ID Code:36681
Deposited By: Nabilah Mustapa
Deposited On:06 Apr 2016 12:25
Last Modified:06 Apr 2016 12:25

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