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Anti–elastase, anti–tyrosinase and matrix metalloproteinase–1 inhibitory activity of earthworm extracts as potential new anti–aging agent

Azmi, Nurhazirah and Hashim, Puziah and Mat Hashim, Dzulkifly and Halimoon, Normala and Nik Ab. Majid, Nik Muhamad (2014) Anti–elastase, anti–tyrosinase and matrix metalloproteinase–1 inhibitory activity of earthworm extracts as potential new anti–aging agent. Asian Pacific Journal of Tropical Biomedicine, 4 (suppl.1). S348-S352. ISSN 2221-1691

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Abstract

Objective: To examine whether earthworms of Eisenia fetida, Lumbricus rubellus and Eudrilus eugeniae extracts have elastase, tyrosinase and matrix metalloproteinase-1 (MMP-1) inhibitory activity. Methods: The earthworms extract was screened for elastase, tyrosinase and MMP-1 inhibitory activity and compared with the positive controls. It was also evaluated for whitening and anti-wrinkle capacity. Results: The extract showed significantly (P<0.05) good elastase and tyrosinase inhibition and excellent MMP-1 inhibition compared to N-Isobutyl-N-(4-methoxyphenylsulfonyl)-glycylhydroxamic acid. Conclusions: Earthworms extract showed effective inhibition of tyrosinase, elastase and MMP-1 activities. Therefore, this experiment further rationalizes the traditional use of this worm extracts which may be useful as an anti-wrinkle agent.

Item Type:Article
Keyword:Earthworms; Ageing; Elastase; Matrix metalloproteinase-1; Anti-wrinkle agent
Faculty or Institute:Faculty of Environmental Studies
Faculty of Forestry
Halal Products Research Institute
Institute of Tropical Forestry and Forest Products
Publisher:Asian Pacific Journal of Tropical Biomedicine Editorial Office
DOI Number:10.12980/APJTB.4.2014C1166
Altmetrics:http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.12980/APJTB.4.2014C1166
ID Code:36474
Deposited By: Nabilah Mustapa
Deposited On:14 Aug 2015 19:34
Last Modified:24 Aug 2015 11:24

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