UPM Institutional Repository

Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome


Citation

Tan, Kai Leng and Ling, King Hwa and Hewitt, Chelsee A. and Cheah , Pike See and Simpson, Ken M. and Gordon, Lavinia and Pritchard, Melanie A. and Smyth, Gordon K. and Thomas, Tim and Scott, Hamish S. (2014) Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome. Genomics Data, 2. pp. 314-317. ISSN 2213-5960

Abstract

The Ts1Cje mouse model of Down syndrome (DS) has partial trisomy of mouse chromosome 16 (MMU16), which is syntenic to human chromosome 21 (HSA21). It develops various neuropathological features demonstrated by DS patients such as reduced cerebellar volume [1] and altered hippocampus-dependent learning and memory [2] and [3]. To understand the global gene expression effect of the partially triplicated MMU16 segment on mouse brain development, we performed the spatiotemporal transcriptome analysis of Ts1Cje and disomic control cerebral cortex, cerebellum and hippocampus harvested at four developmental time-points: postnatal day (P)1, P15, P30 and P84. Here, we provide a detailed description of the experimental and analysis procedures of the microarray dataset, which has been deposited in the Gene Expression Omnibus (GSE49050) database.


Download File

[img] PDF
Transcriptional profiling of the postnatal brain of the Ts1Cje mouse.pdf
Restricted to Repository staff only

Download (488kB)

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1016/j.gdata.2014.09.009
Publisher: Elsevier
Keywords: Down syndrome; Microarray; Postnatal brain; Gene expression
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 11 Feb 2016 04:44
Last Modified: 11 Feb 2016 04:44
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.gdata.2014.09.009
URI: http://psasir.upm.edu.my/id/eprint/35883
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item