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Stability of positively charged nanoemulsion formulation containing steroidal drug for effective transdermal application


Citation

Da Costa, Stephanie and Basri, Mahiran and Shamsudin, Norashikin and Basri, Hamidon (2014) Stability of positively charged nanoemulsion formulation containing steroidal drug for effective transdermal application. Journal of Chemistry, 2014. art. no. 748680. pp. 1-8. ISSN 2090-9063; ESSN: 2090-9071

Abstract

This paper emphasizes the formation of a positively charged nanoemulsion system for steroid drugs (hydrocortisone). It is believed that positively charged nanoemulsion provides more effective penetration of the skin. Therefore in our study we focused on the incorporation of phytosphingosine which serves as a positively charged cosurfactant in the nanoemulsion system. Negatively charged nanoemulsions were formulated mainly for comparison. Freshly prepared formulations were formed with particle size less than 300 nm and showed good stability over time. The oil-in-water nanoemulsion also showed good viscosity, conductivity, and pH values. From TEM micrograph, particle size showed consistent results with the measurement using photon correlation spectroscopy. It was concluded that both positively and negatively charged nanoemulsions showed good stability and have great potential in transdermal delivery system. Though, further investigation of the drug release and drug penetration of both positively and negatively charged nanoemulsions will be studied to further prove the efficacy of nanoemulsion with hydrocortisone as a delivery system for dermal application.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Faculty of Science
Institute of Bioscience
DOI Number: https://doi.org/10.1155/2014/748680
Publisher: Hindawi Publishing Corporation
Keywords: Nanoemulsion system; Steroidal drug; Drug penetration
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 11 Jan 2016 02:07
Last Modified: 11 Jan 2016 02:07
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2014/748680
URI: http://psasir.upm.edu.my/id/eprint/35448
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