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Non-specific immunostimulatory capacity of Newcastle disease virus (NDV) and suppression of breast cancer cells

Ahmed, Ismaila and Ahmad, Umar and Othman, Fauziah and Yong, Yoke Keong (2014) Non-specific immunostimulatory capacity of Newcastle disease virus (NDV) and suppression of breast cancer cells. International Journal of Pharmaceutical an d Clinical Research, 6 (3). pp. 196-200. ISSN 0975-1556

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Official URL: http://ijpcr.com/volume6issue3/

Abstract

Newcastle disease virus (NDV) is an enveloped single stranded RNA virus that causes deadly infection to over 250 species of birds, comprising domestic and wild-type, thus resulting in substantial economic loss to poultry industry across the globe. NDV possesses several distinctive properties that make it an outstanding anti-cancer agent. In humans it is reported to have oncolytic and immune-stimulatory effects, precisely replicates in tumour cells while sparing normal cells and causes oncolysis. Although NDV has been extensively studied by researchers there is still need for a vigorous research on its potential use as a new treatment modality to cancer patients through a known process termed viroimmunotherapy. This paper deals with an overview of the research which has been carried out worldwide in the use of immune-stimulatory properties of NDV as an anti-cancer agent.

Item Type:Article
Keyword:Newcastle disease virus; Immune-stimulation; Anti-cancer; Cytokines
Faculty or Institute:Faculty of Medicine and Health Science
Publisher:International Journal of Pharmaceutical and Clinical Research
ID Code:34667
Deposited By: Nurul Ainie Mokhtar
Deposited On:18 Dec 2015 08:17
Last Modified:18 Dec 2015 08:17

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