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Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review


Citation

Pandurangan, Ashok Kumar and Mohd Esa, Norhaizan (2014) Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review. Asian Pacific Journal of Cancer Prevention, 15 (14). pp. 5501-5508. ISSN 1513-7368

Abstract

Luteolin, 3’, 4’, 5,7-tetrahydroxyflavone, belongs to a group of naturally occurring compounds called flavonoids that are found widely in the plant kingdom. It possesses many beneficial properties including antioxidant, antiinflammatory, anti-bacterial, anti-diabetic and anti-proliferative actions. Colorectal cancer (CRC) is a leading cause of cancer related deaths worldwide. Many signaling pathways are deregulated during the progression of colon cancer. In this review we aimed to analyze the protection offered by luteolin on colon cancer. During colon cancer genesis, luteolin known to reduce oxidative stress thereby protects the cell to undergo damage in vivo. Wnt/β-catenin signaling, deregulated during neoplastic development, is modified by luteolin. Hence, luteolin can be considered as a potential drug to treat CRC.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Institute of Bioscience
DOI Number: https://doi.org/10.7314/APJCP.2014.15.14.5501
Publisher: Asian Pacific Education Press Ltd.
Keywords: Luteolin; Colon cancer; Wnt/β-catenin; Nrf2
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 15 Dec 2015 01:05
Last Modified: 15 Dec 2015 01:05
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.7314/APJCP.2014.15.14.5501
URI: http://psasir.upm.edu.my/id/eprint/34405
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