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Induction of epoxide hydrolase, glucuronosyl transferase and sulfotransferase by phenethyl isothiocyanate in male Wistar albino rats

Abdull Razis, Ahmad Faizal and Mohd Noor, Noramaliza and Konsue, Nattaya (2014) Induction of epoxide hydrolase, glucuronosyl transferase and sulfotransferase by phenethyl isothiocyanate in male Wistar albino rats. BioMed Research International, 2014 . art. no. 391528. pp. 1-5. ISSN 2314-6133; ESSN: 2314-6141

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Abstract

Phenethyl isothiocyanate (PEITC) is an isothiocyanate found in watercress as the glucosinolate (gluconasturtiin). The isothiocyanate is converted from the glucosinolate by intestinal microflora or when contacted with myrosinase during the chopping and mastication of the vegetable. PEITC manifested protection against chemically-induced cancers in various tissues. A potential mechanism of chemoprevention is by modulating the metabolism of carcinogens so as to promote deactivation. The principal objective of this study was to investigate in rats the effect of PEITC on carcinogen-metabolising enzyme systems such as sulfotransferase (SULT), N-acetyltransferase (NAT), glucuronosyl transferase (UDP), and epoxide hydrolase (EH) following exposure to low doses that simulate human dietary intake. Rats were fed for 2 weeks diets supplemented with PEITC at 0.06 µmol/g (low dose, i.e., dietary intake), 0.6 µmol/g (medium dose), and 6.0 µmol/g (high dose), and the enzymes were monitored in rat liver. At the Low dose, no induction of the SULT, NAT, and EH was noted, whereas UDP level was elevated. At the Medium dose, only SULT level was increased, whereas at the High dose marked increase in EH level was observed. It is concluded that PEITC modulates carcinogen-metabolising enzyme systems at doses reflecting human intake thus elucidating the mechanism of its chemoprevention.

Item Type:Article
Keyword:Epoxide hydrolase; Glucuronosyl transferase; Sulfotransferase; Phenethyl isothiocyanate; Wistar albino rat
Faculty or Institute:Faculty of Food Science and Technology
Faculty of Medicine and Health Science
Publisher:Hindawi Publishing Corporation
DOI Number:10.1155/2014/391528
Altmetrics:http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2014/391528
ID Code:34170
Deposited By: Nurul Ainie Mokhtar
Deposited On:07 Dec 2015 16:25
Last Modified:07 Dec 2015 16:25

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