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In vitro sustained release study of gallic acid coated with magnetite-PEG and magnetite-PVA for drug delivery system


Citation

Dorniani, Dena and Kura, Aminu Umar and Hussein-Al-Ali, Samer Hasan and Hussein, Mohd Zobir and Fakurazi, Sharida and Shaari, Abdul Halim and Ahmad, Zalinah (2014) In vitro sustained release study of gallic acid coated with magnetite-PEG and magnetite-PVA for drug delivery system. The Scientific World Journal, 2014. art. no. 416354. pp. 1-11. ISSN 2356-6140; ESSN: 1537-744X

Abstract

The efficacy of two nanocarriers polyethylene glycol and polyvinyl alcohol magnetic nanoparticles coated with gallic acid (GA) was accomplished via X-ray diffraction, infrared spectroscopy, magnetic measurements, thermal analysis, and TEM. X-ray diffraction and TEM results showed that Fe3O4 nanoparticles were pure iron oxide having spherical shape with the average diameter of 9 nm, compared with 31 nm and 35 nm after coating with polyethylene glycol-GA (FPEGG) and polyvinyl alcohol-GA (FPVAG), respectively. Thermogravimetric analyses proved that after coating the thermal stability was markedly enhanced. Magnetic measurements and Fourier transform infrared (FTIR) revealed that superparamagnetic iron oxide nanoparticles could be successfully coated with two polymers (PEG and PVA) and gallic acid as an active drug. Release behavior of gallic acid from two nanocomposites showed that FPEGG and FPVAG nanocomposites were found to be sustained and governed by pseudo-second-order kinetics. Anticancer activity of the two nanocomposites shows that the FPEGG demonstrated higher anticancer effect on the breast cancer cell lines in almost all concentrations tested compared to FPVAG.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Faculty of Science
Institute of Advanced Technology
Institute of Bioscience
DOI Number: https://doi.org/10.1155/2014/416354
Publisher: Hindawi Publishing Corporation
Keywords: Gallic acid; Magnetite-PEG; Magnetite-PVA; Drug delivery system
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 07 Dec 2015 06:53
Last Modified: 07 Dec 2015 06:53
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2014/416354
URI: http://psasir.upm.edu.my/id/eprint/34152
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