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Novel compound for use as medicament for treatment of hypercholesterolemia and atherosclerosis

Mohd. Yunus Abd. Shukor. (2014) Novel compound for use as medicament for treatment of hypercholesterolemia and atherosclerosis.

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Abstract

The present invention provides a novel compound apigenin 5-O-a-arabinofuranosyl-8-C-b-glucopyranoside (AAG). AAG is usable for treatment or prevention of hypercholesterolemia and atherosclerosis. AAG can be isolated from an edible medicinal plant, Basella alba L. and was shown to be non toxic in cytotoxicity (in vitro), acute and sub-chronic toxicity studies (in vivo). The novel compound showed more than 80% inhibitory effect on activity of HMG-CoA reductase and able to treat hypercholesterolemia by lowering total cholesterol (TC), Low density lipoprotein (LDL) and triglyceride (TG) level in serum and significantly reduces the plaque formation in the aorta.

Item Type:Patent
Keyword:Formulation; In vivo treatment of hypercholesterolemia and arterosclerosis
Faculty or Institute:Faculty of Biotechnology and Biomolecular Sciences
Application Number:PI2014704025
Filing Date:2014-12-28
ID Code:33996
Deposited By: Mohd Hafiz Che Mahasan
Deposited On:28 Apr 2015 18:33
Last Modified:21 Nov 2016 11:09

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