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GLP-1 promoter mediated insulin expression for the treatment of diabetes.


Citation

Zalinah Ahmad (2010) GLP-1 promoter mediated insulin expression for the treatment of diabetes. .

Abstract / Synopsis

Insulin gene therapy is one of many envisioned alternative treatments of diabetes. Diabetes gene therapy would be possible if insulin could be produced in a regulated and specifically in a sensitive manner dependent on the blood glucose level.Therefore, the present invention relates to a method for the isolation of GLP-1 expressing cells, to nucleic acids sequence construction or vectors useful for isolating GLP-1 expressing cell and to the GLP-1 expressing cells isolated therewith. Furthermore, the inventions relates to a method of nucleic acids sequence construction or vectors under the control of the GLP-1 promoter expressing insulin in a recombinant GLP-1 expressing cell line. The cells of the present invention are particular useful for the treatment of diabetes and may be used in a gene therapy approach to treat diabetes and other disorders related to the nutrient metabloism.


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Additional Metadata

Item Type: Patent
Divisions: Faculty of Medicine and Health Science
Keywords: GLP-1; Insulin; Diabetes.
Depositing User: Junaini Mohd Yusof
Date Deposited: 07 Oct 2014 09:48
Last Modified: 07 Oct 2014 09:48
URI: http://psasir.upm.edu.my/id/eprint/32198
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