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Enhanced antigenicity of Nipah virus nucleocapsid protein displayed on hepatitis B core antigen


Citation

Yap, Wei Boon and Tey, Beng Ti and Mohammed Alitheen, Noorjahan Banu and Tan, Wen Siang (2012) Enhanced antigenicity of Nipah virus nucleocapsid protein displayed on hepatitis B core antigen. In: International Conference on One Health and 24th VAM Congress 2012, 21-23 Sept. 2012, Marriott Putrajaya. (pp. 324-326).

Abstract

Display of the nucleocapsid protein (NP) of Nipah virus (NiV) on the hepatitis B core (HBc) particle enhances the antigenicity of the NP. In addition, the NP fused to the amino-teminus (NP401-532 HBc) and immunodominant loop of HBc (HBc79.80NP4O1'S31) was shown to be less sensitive to proteinase K. Some of the proteinase K treated NP401.32HBc and HBc79.80NP,O].s32 remained intact and antigenic. These results indicated two important implications, (1) the use of HBc virus -like particle as a carrier platform for foreign epitopes, (2 ) the use of NP401.532HBc as a diagnostic reagent for NiV infection.


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Additional Metadata

Item Type: Conference or Workshop Item (Paper)
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Institute of Bioscience
Notes: Full text are available at Special Collection Division Office.
Keywords: Nipah virus; Fusion protein; Nucleocapsid; Hepatitis B core antigen; Virus-like particles
Depositing User: Samsida Samsudin
Date Deposited: 03 Sep 2014 01:29
Last Modified: 09 Jan 2017 09:33
URI: http://psasir.upm.edu.my/id/eprint/31947
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