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Functional polyaniline nanofibre mats for human adipose-derived stem cell proliferation and adhesion

Abdul Rahman, Norizah and Feisst, Vaughan and Dickinson, Michelle E. and Malmstrom, Jenny and Dunbar, P. Rod and Travas Sejdic, Jadranka (2013) Functional polyaniline nanofibre mats for human adipose-derived stem cell proliferation and adhesion. Materials Chemistry and Physics, 138 (1). pp. 333-341. ISSN 0254-0584

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Abstract

Conductive polymer poly(aniline-co-m-aminobenzoic acid) (P(ANI-co-m-ABA)) and polyaniline (PANI) were blended with a biodegradable, biocompatible polymer, poly(l-lactic acid) and were electrospun into nanofibres to investigate their potential application as a scaffold for human adipose-derived stem cells (hASCs). These polymers, in both conductive and non-conductive form, were electrospun with average fibre diameters of less than 400 nm. Novel nanoindentation results obtained on the individual nanofibres revealed that the elastic moduli of the nanofibres are much higher at the surface (4–10 GPa, hmax <75 nm) than in the inner fibre core (2–4 GPa, hmax >75 nm). The composite nanofibres showed great promise as a scaffold for hASCs as they supported the cell adhesion and proliferation. After 1 week of cell culture hASCs were well spread on the substrates with abundant focal adhesions. The electrospun mats provide the cells with comparably stiff, sub-micron sized fibres as anchoring points on a substrate of high porosity. The conductive nature of these composite nanofibres offers exciting opportunities for electrical stimulation of the cells.

Item Type:Article
Keyword:Biomaterials; Electronic materials; Nanostructures; Polymers.
Faculty or Institute:Faculty of Science
Publisher:Elsevier
DOI Number:10.1016/j.matchemphys.2012.11.065
Altmetrics:http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.matchemphys.2012.11.065
ID Code:30165
Deposited By: Umikalthom Abdullah
Deposited On:04 Jul 2014 09:28
Last Modified:10 Sep 2015 16:01

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