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Molecular pathways governing development of vascular endothelial cells from ES/iPS cells


Citation

Tan, Keai Sinn and Tamura, Kiyomi and Lai, Mei I. and Veerakumarasivam, Abhimanyu and Nakanishi, Yoichi and Ogawa, Minetaro and Sugiyama, Daisuke (2013) Molecular pathways governing development of vascular endothelial cells from ES/iPS cells. Stem Cell Reviews and Reports, 9 (5). pp. 586-598. ISSN 1550-8943; ESSN: 1558-6804

Abstract

Assembly of complex vascular networks occurs in numerous biological systems through morphogenetic processes such as vasculogenesis, angiogenesis and vascular remodeling. Pluripotent stem cells such as embryonic stem (ES) and induced pluripotent stem (iPS) cells can differentiate into any cell type, including endothelial cells (ECs), and have been extensively used as in vitro models to analyze molecular mechanisms underlying EC generation and differentiation. The emergence of these promising new approaches suggests that ECs could be used in clinical therapy. Much evidence suggests that ES/iPS cell differentiation into ECs in vitro mimics the in vivo vascular morphogenic process. Through sequential steps of maturation, ECs derived from ES/iPS cells can be further differentiated into arterial, venous, capillary and lymphatic ECs, as well as smooth muscle cells. Here, we review EC development from ES/iPS cells with special attention to molecular pathways functioning in EC specification.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Institute of Bioscience
DOI Number: https://doi.org/10.1007/s12015-013-9450-7
Publisher: Springer
Keywords: Endothelial cells; Differentiation; Molecular pathways; Embryonic stem cells; Induced pluripotent stem cells
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 25 May 2015 00:10
Last Modified: 29 Dec 2015 04:42
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1007/s12015-013-9450-7
URI: http://psasir.upm.edu.my/id/eprint/29663
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