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Assessment of antioxidant and cytotoxicity activities of saponin and crude extracts of Chlorophytum birivilianum


Citation

Ashraf, Mehdi Farshad and Abdul Aziz, Maheran and Stanslas, Johnson and Ismail, Ismanizam and Abdul Kadir, Mihdzar (2013) Assessment of antioxidant and cytotoxicity activities of saponin and crude extracts of Chlorophytum birivilianum. The Scientific World Journal, 2013. art. no. 216894. pp. 1-7. ISSN 2356-6140; ESSN: 1537-744X

Abstract / Synopsis

The present paper focused on antioxidant and cytotoxicity assessment of crude and total saponin fraction of Chlorophytum borivilianum as an important medicinal plant. In this study, three different antioxidant activities (2,2-diphenyl-1-picrylhydrazyl radical scavenging (DPPH), ferrous ion chelating (FIC), and β-carotene bleaching (BCB) activity) of crude extract and total saponin fraction of C. borivilianum tubers were performed. Crude extract was found to possess higher free radical scavenging activity (ascorbic acid equivalents 2578 ± 111 mg AA/100 g) and bleaching activity (IC50 = 0.7 mg mL−1), while total saponin fraction displayed higher ferrous ion chelating (EC50 = 1 mg mL−1). Cytotoxicity evaluation of crude extract and total saponin fraction against MCF-7, PC3, and HCT-116 cancer cell lines using 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) cell viability assay indicated a higher cytotoxicity activity of the crude extract than the total saponin fraction on all cell lines, being most effective and selective on MCF-7 human breast cancer cell line.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Agriculture
Faculty of Medicine and Health Science
Institute of Tropical Agriculture
DOI Number: 10.1155/2013/216894
Publisher: Hindawi Publishing Corporation
Keywords: Antioxidant; Cytotoxicity activities; Saponin; Crude extract; Chlorophytum birivilianum
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 25 May 2015 12:16
Last Modified: 26 Apr 2017 17:19
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2013/216894
URI: http://psasir.upm.edu.my/id/eprint/29631
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