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Assessment of antioxidant and cytotoxicity activities of saponin and crude extracts of Chlorophytum birivilianum

Ashraf, Mehdi Farshad and Abd Aziz, Maheran and Stanslas, Johnson and Ismail, Ismanizam and Abdul Kadir, Mihdzar (2013) Assessment of antioxidant and cytotoxicity activities of saponin and crude extracts of Chlorophytum birivilianum. The Scientific World Journal, 2013 . art. no. 216894. pp. 1-7. ISSN 2356-6140; ESSN: 1537-744X

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Official URL: http://www.hindawi.com/journals/tswj/2013/216894/

Abstract

The present paper focused on antioxidant and cytotoxicity assessment of crude and total saponin fraction of Chlorophytum borivilianum as an important medicinal plant. In this study, three different antioxidant activities (2,2-diphenyl-1-picrylhydrazyl radical scavenging (DPPH), ferrous ion chelating (FIC), and β-carotene bleaching (BCB) activity) of crude extract and total saponin fraction of C. borivilianum tubers were performed. Crude extract was found to possess higher free radical scavenging activity (ascorbic acid equivalents 2578 ± 111 mg AA/100 g) and bleaching activity (IC50 = 0.7 mg mL−1), while total saponin fraction displayed higher ferrous ion chelating (EC50 = 1 mg mL−1). Cytotoxicity evaluation of crude extract and total saponin fraction against MCF-7, PC3, and HCT-116 cancer cell lines using 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) cell viability assay indicated a higher cytotoxicity activity of the crude extract than the total saponin fraction on all cell lines, being most effective and selective on MCF-7 human breast cancer cell line.

Item Type:Article
Keyword:Antioxidant; Cytotoxicity activities; Saponin; Crude extract; Chlorophytum birivilianum
Faculty or Institute:Faculty of Agriculture
Faculty of Medicine and Health Science
Institute of Tropical Agriculture
Publisher:Hindawi Publishing Corporation
DOI Number:10.1155/2013/216894
Altmetrics:http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2013/216894
ID Code:29631
Deposited By: Nurul Ainie Mokhtar
Deposited On:25 May 2015 12:16
Last Modified:08 Sep 2015 13:52

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