Simple Search:

Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers.


Citation

Ab Mutalib, Nurul-Syakima and Cheah, Yoke Kqueen and Abdul Rahman, Sabariah and Mohd Sidik, Shiran and Mohan Singh, Avatar Singh and Lee, Learn Han (2011) Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers. International Journal of Molecular Medicine, 28 (3). pp. 327-336. ISSN 1107-3756; ESSN:1791-244X

Abstract / Synopsis

MicroRNAs (miRNAs) are small noncoding RNAs that involved in various cancer-related cellular processes. Diverse studies on expression profiling of miRNAs have been performed and the data showed that some miRNAs are up-regulated or down-regulated in cancer. Until now, there are no data published on the miRNA expression in head and neck cancers from Malaysia. Hence, this study aimed to investigate potentially crucial miRNAs in head and neck cancer patients from Malaysian populations. A global miRNA profiling was performed on 12 samples of head and neck cancer tissue using microarray analysis followed by validation using real-time RT-PCR Microarray analysis identified 10 miRNAs that could distinguish malignant head and neck cancer lesions from normal tissues; 7 miRNAs (hsa-miR-181a-2*, hsa-miR-29b-1*, hsa-miR-181a, hsa-miR-181b, hsa-miR-744, hsa-miR-1271 and hsa-miR-221*) were up-regulated while 3 miRNAs (hsa-miR-141, hsa-miR-95 and hsa-miR-101) were down-regulated. These miRNAs may contribute in a simple profiling strategy to identify individuals at higher risk of developing head and neck cancers, thus helping in the elucidation of the molecular mechanisms involved in head and neck cancer pathogenesis.


Download File

[img]
Preview
PDF (Abstract)
Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers.pdf

Download (85kB) | Preview

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: 10.3892/ijmm.2011.714
Publisher: Spandidos Publications
Keywords: MicroRNA; Head and neck cancers; Microarray; Quanti-tative reverse transcription-PCRcr; In silico analysis.
Depositing User: Nur Farahin Ramli
Date Deposited: 12 Sep 2013 14:38
Last Modified: 30 Jun 2016 13:09
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3892/ijmm.2011.714
URI: http://psasir.upm.edu.my/id/eprint/24723
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item