Keyword Search:


Bookmark and Share

Carica papaya increases regulatory T cells and reduces IFN-ã+ CD4+ T cells in healthy human subjects.

Abdullah, Maha and Kandiah, Mirnalini and Vidyadaran, Sharmili and Seow, Heng Fong and Seman, Zainina and Chai, Pei Shin and Loh, Chiew Yee and Chong, Mun Yee and Quay, Huai Wei (2011) Carica papaya increases regulatory T cells and reduces IFN-ã+ CD4+ T cells in healthy human subjects. Molecular Nutrition and Food Research , 55 (5). pp. 803-806. ISSN 1613-4125; ESSN:1613-4133

[img] PDF (Abstract)
182Kb

Official URL: http://www.wiley-vch.de/publish/en/

Abstract

Fruit and vegetables have therapeutic potential as they dampen inflammation, have no known side-effects and as whole foods have prospective additive and synergistic benefits. Th1 (IFN-γ(+) CD4(+))/Th2 (IL-4(+)CD4(+)) T cells play a vital role in mediating inflammatory responses and may be regulated by regulatory T cells (Tregs). Effects of Carica papaya on cells of healthy individuals were determined using flow cytometry methods. Significant down-regulation of IFN-γ(+) CD4(+) (p=0.03, n=13), up-regulation of IL-4(+) CD4(+) (p=0.04, n=13) T cells and up-regulation of CD3(+) CD4(+) CD25(+) CD127(-) (p=0.001, n=15) Tregs were observed after papaya consumption. In vitro cultures showed up-regulation of Tregs in male subjects and was significantly associated with levels of IL-1β in culture supernatants (R(2) =0.608, p=0.04, n=12). Other inflammatory cytokines were significantly suppressed. Papaya consumption may exert an anti-inflammatory response mediated through Tregs and have potential in alleviating inflammatory conditions.

Item Type:Article
Keyword:Carica papaya; Healthy human subjects.
Faculty or Institute:Faculty of Medicine and Health Science
Publisher:Wiley-VCH Verlag
ID Code:24615
Deposited By: Nur Farahin Ramli
Deposited On:23 Sep 2013 17:57
Last Modified:06 Oct 2015 15:44

Repository Staff Only: Edit item detail

Document Download Statistics

This item has been downloaded for since 23 Sep 2013 17:57.

View statistics for "Carica papaya increases regulatory T cells and reduces IFN-ã+ CD4+ T cells in healthy human subjects."