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Quantifying the effects of iodine contrast media on standardised uptake values of FDG PET/CT images : an anthropomorphic phantom study.

Abdul Razak, Hairil Rashmizal and Nordin, Abdul Jalil and Ackerly, Trevor and Van Every, Bruce and Martin, Ruth and Geso, Moshi (2011) Quantifying the effects of iodine contrast media on standardised uptake values of FDG PET/CT images : an anthropomorphic phantom study. Australasian Physical & Engineering Sciences in Medicine, 34 (3). pp. 367-374. ISSN 0158-9938; ESSN: 1879-5447

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Abstract

This study aimed to quantify the amount of change in Standardised Uptake Values (SUVs) of PET/CT images by simulating the set-up as closely as possible to the actual patient scanning. The experiments were conducted using an anthropomorphic phantom, which contained an amount of radioactivity in the form of Fluorodeoxyglucose (FDG) in a primary plastic test tube and one litre saline bags, including the insertion of bony structures and another two test tubes containing different concentrations of iodine contrast media. Standard scanning protocols were employed for the PET/CT image acquisition. The highest absolute differences in the SUVmax and SUVmean values of the saline bags were found to be about 0.2 and 0.4, respectively. The primary test tube showed the largest change of 1.5 in both SUVs; SUV max and SUVmean. However, none of these changes were found to be statistically significant. The clinical literature also contains no evidence to suggest that the changes of this magnitude would change the final diagnosis. Based on these preliminary data, we propose that iodine contrast media can be used during the CT scan of PET/CT imaging, without significantly affecting the diagnostic quality of this integrated imaging modality.

Item Type:Article
Keyword:Iodine contrast media; Standardised Uptake Values; PET/CT; SUVmax; SUVmean.
Faculty or Institute:Faculty of Medicine and Health Science
Publisher:Springer Verlag
DOI Number:10.1007/s13246-011-0088-y
Altmetrics:http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1007/s13246-011-0088-y
ID Code:24536
Deposited By: Nur Farahin Ramli
Deposited On:25 Mar 2014 16:49
Last Modified:29 Sep 2015 15:42

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