Citation
Vasudevan, R. and M. N., Norhasniza and Ismail, Patimah
(2011)
Association of variable number of tandem repeats polymorphism in the IL-4 gene with end-stage renal disease in Malaysian patients.
Genetics and Molecular Research, 10 (2).
pp. 943-947.
ISSN 1676-5680
Abstract
Variable number of tandem repeats (VNTR) polymorphism in the interleukin 4 (IL-4) gene has been associated with end-stage renal disease (ESRD) subjects in many different populations, although with conflicting results. We determined the 70 bp of VNTR polymorphism at intron 3 of the IL-4 gene in Malaysian ESRD subjects. Buccal cells were collected from 160 case and 160 control subjects; genomic DNA was amplified using PCR, followed by agarose gel electrophoresis. There were significant differences in genotypes and alleles of the IL-4 gene. We conclude that VNTR polymorphism of the IL-4 gene is a risk factor for the development of ESRD among Malaysians.
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Medicine and Health Science |
| DOI Number: | https://doi.org/10.4238/vol10-2gmr1066 |
| Publisher: | Fundacao de Pesquisas Cientificas de Ribeirao Preto |
| Keywords: | Genetic polymorphism; VNTR; ESRD; Interleukin' |
| Depositing User: | Nur Farahin Ramli |
| Date Deposited: | 30 Mar 2014 13:15 |
| Last Modified: | 07 Oct 2015 04:34 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.4238/vol10-2gmr1066 |
| URI: | http://psasir.upm.edu.my/id/eprint/24418 |
| Statistic Details: | View Download Statistic |
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