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Novel in-vitro antimicrobial activity of Vigna radiata (L.)R. Wilczek against highly resistant bacterial and fungal pthogens.

Abu Bakar, Fatimah and Abas, Faridah and Sekawi, Zamberi and Hafidh, Rand Riadh and A. S., Abdulamir and Law, Se Vern (2011) Novel in-vitro antimicrobial activity of Vigna radiata (L.)R. Wilczek against highly resistant bacterial and fungal pthogens. Journal of Medicinal Plants Research, 5 (16). pp. 3606-3618. ISSN 1996-0875

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Abstract

The ever rising resistant bacteria and fungi resulted in finding novel antimicrobial sources and agents. Studies confirmed that mung beans have increased phenolic compounds and enhanced defenses during germination. We hypothesized that antimicrobial activities might be found in sprouts of mung beans (MBS), or Vigna radiata (L.) R. Wilczek. The screening method was conducted using disc diffusion assay against 12 gram negative and positive bacteria, including multiple drug resistant (MDR) bacteria and 12 fungi. It was followed by the evaluation of the minimum inhibitory concentration and the minimum bactericidal concentration or the minimum fungicidal concentration. The screening results revealed potential antibacterial and antifungal activities by MBS extract against 11 out of 12 bacteria and 2 out of 10 fungi including remarkable antimicrobial activity against highly infectious MDR bugs such as Methicilline-resistant Staphylococcus aureus, MDR Escherichia coli O157:H7, MDR Pseudomonas aeruginosa, Klebsiella pneumoniae, S. aureus, and Salmonella Typhimurium as well as against human fungal pathogens, Trichophyton rubrum and Trichoderma harzianum. The potential antimicrobial activity of MBS reflects effective quality and quantity of polyphenolic compounds present after bean germination. This unprecedented study showed that MBS extract is a potential source for novel antimicrobials that are inexpensive and readily available at a large scale for pharmaceutical companies.

Item Type:Article
Keyword:Antimicrobial; Antifungal; Multiple drug resistant; Mung bean sprout; Polyphenols.
Faculty or Institute:Faculty of Food Science and Technology
Publisher:Academic Journals
ID Code:24121
Deposited By: Nur Farahin Ramli
Deposited On:24 Oct 2013 08:43
Last Modified:30 Sep 2015 09:57

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