Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus var. citroides: role of reactive nitrogen species and cyclooxygenase enzymes inhibition
Abdelwahab, Siddig Ibrahim and Ahmed Hassan, Loiy Elsir and Mohd Sirat, Hasnah and Mohamed Ahmed Yagi, Sakina and Mohamed, Waleed Sayed Koko and Mohan, Syam and Taha, Manal Mohamed Elhassan and Ahmad, Syahida and Cheah, Shiau Chuen and Mohd Fauzi, Putri Narrima and Rais, Mohd Mustafa and A. Hadi, A. Hamid (2011) Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus var. citroides: role of reactive nitrogen species and cyclooxygenase enzymes inhibition. Fitoterapia, 82 (8). pp. 1190-1197. ISSN 0367-326X; ESSN: 1873-6971
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The in vivo and in vitro mechanistic anti-inflammatory actions of cucurbitacin E (CE) (Citrullus lanatus var. citroides) were examined. The results showed that LPS/INF-γ increased NO production in RAW264.7 macrophages, whereas L-NAME and CE curtailed it. CE did not reveal any cytotoxicity on RAW264.7 and WRL-68 cells. CE inhibited both COX enzymes with more selectivity toward COX-2. Intraperitoneal injection of CE significantly suppressed carrageenan-induced rat's paw edema. ORAC and FRAP assays showed that CE is not a potent ROS scavenger. It could be concluded that CE is potentially useful in treating inflammation through the inhibition of COX and RNS but not ROS.
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