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Chemometric analysis of lipase-catalyzed synthesis of xylitol esters in a solvent-free system

Adnani, Atena and Basri, Mahiran and Chaibakhsh, Naz and Ahangar, Hossein Abbastabar and Salleh, Abu Bakar and Raja Abdul Rahman, Raja Noor Zaliha and Abdul Rahman, Mohd Basyaruddin (2011) Chemometric analysis of lipase-catalyzed synthesis of xylitol esters in a solvent-free system. Carbohydrate Research, 346 (4). pp. 472-479. ISSN 0008-6215; ESSN: 1873-426X

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Abstract

Immobilized Candida antarctica lipase B-catalyzed esterification of xylitol and two fatty acids (capric and caproic acid) were studied in a solvent-free system. The Taguchi orthogonal array method based on three-level-four-variables with nine experiments was applied for the analysis and optimization of the reaction parameters including time, substrate molar ratio, amount of enzyme, and amount of molecular sieve. The obtained conversion was higher in the esterification of xylitol and capric acid with longer chain length. The optimum conditions derived via the Taguchi approach for the synthesis of xylitol caprate and xylitol caproate were reaction time, 29 and 18 h; substrate molar ratio, 0.3 and 1.0; enzyme amount, 0.20 and 0.05 g, and molecular sieve amount of 0.03 g, respectively. The good correlation between the predicted conversions (74.18% and 61.23%) and the actual values (74.05% and 60.5%) shows that the model derived from the Taguchi orthogonal array can be used for optimization and better understanding of the effect of reaction parameters on the enzymatic synthesis of xylitol esters in a solvent-free system.

Item Type:Article
Keyword:Esterification; Lipase; Xylitol esters; Solvent-free system; Optimization; Taguchi method
Faculty or Institute:Faculty of Biotechnology and Biomolecular Sciences
Faculty of Science
Publisher:Elsevier
DOI Number:10.1016/j.carres.2010.12.023
Altmetrics:http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.carres.2010.12.023
ID Code:22273
Deposited By: Najwani Amir Sariffudin
Deposited On:25 Aug 2014 10:09
Last Modified:27 Sep 2016 12:33

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