The effect of pretreatment of zerumbone on fatty liver following ethanol induced Hepatotoxicity

Citation

Fakurazi, Sharida and Ithnin, Hairuszah and Ganabadi, Shanti and J., Mohd Lip (2008) The effect of pretreatment of zerumbone on fatty liver following ethanol induced Hepatotoxicity. Journal of Biological Sciences, 8 (8). pp. 1348-1351. ISSN 1727-3048, ESSN : 1812-5719

Abstract

This study was designed to determine whether zerumbone, an essential bioactive compound isolated from Zingiber zerumbet Smith protects against early ethanol induced liver injury in rats. Male Sprague-Dawley rats were administered with 0.05% (v/v) to 0.5% (v/v) of zerumbone for 14 days. Following the final dosage of zerumbone, the animals were administered with 50% (v/v) ethanol for 14 days. We have observed that pre-treatment of zerumbone had suppressed fatty liver formation following ethanol 50% (v/v) administration. Meanwhile, rats that were treated with ethanol only, found to show significant level of focal vacuolated fatty liver with focal necrosis in the mid zonal region. Therefore, fatty liver development was found to be extensively reduced in animals that were pretreated with zerumbone.

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Official URL or Download Paper: http://scialert.net/jindex.php?issn=1727-3048

Additional Metadata

Item Type:	Article
Subject:	Ginger - Therapeutic use.
Subject:	Medicinal plants.
Subject:	Fatty liver.
Divisions:	Faculty of Medicine and Health Science
Publisher:	Asian Network for Scientific Information
Keywords:	Zingiber zerumbet; Zerumbone; Hepatotoxicity; Hepatoprotective; Ethanol
Depositing User:	Raja Norazlinda Raja Azenam
Date Deposited:	09 May 2013 01:07
Last Modified:	06 Oct 2015 07:20
URI:	http://psasir.upm.edu.my/id/eprint/17103
Statistic Details:	View Download Statistic

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