UPM Institutional Repository

Silver/poly (lactic acid) nanocomposites: preparation, characterization, and antibacterial activity


Citation

Shameli, Kamyar and Ahmad, Mansor and Wan Yunus, Wan Md. Zin and Ibrahim, Nor Azowa and Abdul Rahman, Russly and Jokar, Maryam and Darroudi, Majid (2010) Silver/poly (lactic acid) nanocomposites: preparation, characterization, and antibacterial activity. International Journal of Nanomedicine, 5. pp. 573-579. ISSN 1176-9114

Abstract

In this study, antibacterial characteristic of silver/poly (lactic acid) nanocomposite (Ag/PLA-NC) films was investigated, while silver nanoparticles (Ag-NPs) were synthesized into biodegradable PLA via chemical reduction method in diphase solvent. Silver nitrate and sodium borohydride were respectively used as a silver precursor and reducing agent in the PLA, which acted as a polymeric matrix and stabilizer. Meanwhile, the properties of Ag/PLA-NCs were studied as a function of the Ag-NP weight percentages (8, 16, and 32 wt% respectively), in relation to the use of PLA. The morphology of the Ag/PLA-NC films and the distribution of the Ag-NPs were also characterized. The silver ions released from the Ag/PLA-NC films and their antibacterial activities were scrutinized. The antibacterial activities of the Ag/PLA-NC films were examined against Gram-negative bacteria (Escherichia coli and Vibrio parahaemolyticus) and Gram-positive bacteria (Staphylococcus aureus) by diffusion method using Muller–Hinton agar. The results indicated that Ag/PLA-NC films possessed a strong antibacterial activity with the increase in the percentage of Ag-NPs in the PLA. Thus, Ag/PLA-NC films can be used as an antibacterial scaffold for tissue engineering and medical application.


Download File

Full text not available from this repository.

Additional Metadata

Item Type: Article
Subject: Nanocomposites (Materials)
Subject: Nanoparticles
Subject: Antibacterial agents
Divisions: Faculty of Science
DOI Number: https://doi.org/10.2147/IJN.S12007
Publisher: Dove Medical Press Ltd.
Keywords: Antibacterial activity; Silver nanoparticles; Biodegradable; Poly (lactic acid); Muller–Hinton agar
Depositing User: Najwani Amir Sariffudin
Date Deposited: 29 Jan 2013 10:11
Last Modified: 29 Jan 2013 10:11
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.2147/IJN.S12007
URI: http://psasir.upm.edu.my/id/eprint/16710
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item